| January 1949 | Department was started by Dr. Jacob Chandy | 
| 1952 | EEG Machine acquired | 
| 1954 | N1 & N2 wards were built | 
| 1957 | Foundation stone for the Department laid | 
| 1957 | Informal training in Neurosurgery began – First Candidate Dr. R.N. Roy | 
| 1958 | Formal training in Neurosurgery (M.S. Neurosurgery) began – First Candidate Dr. K.V. Mathai | 
| 1961 | Stereotactic Surgery initiated | 
| 1964 | Padma Bhushan awarded to Prof. Jacob Chandy | 
| 1966 | Formal training in Neurology began – First Candidate Dr. G.C. Mitra | 
| 1967 | EMG Machine acquired | 
| 1970 | Operating Microscopes Zeiss (OPMI 1) acquired | 
| 1972 | Stroke Rooms built | 
| 1974 | NSI Meeting held in Vellore | 
| 1974 | Silver Jubilee of the Department celebrated | 
| 1975 | Neurophysiology Lab established | 
| 1984 | CUSA, Laser acquired | 
| 1985 | Neurosurgery seats increased from 2 to 3 | 
| 1986 | Evoked Potential Machine acquired | 
| 1987 | First CT guided stereotactic surgery in India | 
| 1987 | First CT guided stereotactic thalamotomy in India | 
| 1988 | Video Telemetry began | 
| 1989 | International SSPE symposium held in Vellore | 
| 1991 | Intraoperative Monitoring began | 
| 1995 | International Mycobacterial symposium held in Vellore | 
| 1995 | Stereotactic radiosurgery began | 
| 1995-1997 | Five Stereotactic workshops held in Vellore | 
| 1997 | Neurophysiology Symposium held in Vellore | 
| 1997 | Neuro-Endoscope acquired | 
| 1999 | Golden Jubilee of the Department celebrated | 
| 2003 | Second CMC Winter Symposium on Neurosciences & Psychiatry held in Vellore | 
| 2004 | Clinical Neurophysiology Workshop on EMG & Intra-Operative Monitoring held in Vellore | 
| 2009 | OR 8 established for extra theatre with full fledged | 
| 2009 | 11th Indian Society for Stereotactic and Functional Neurosurgery Conference held in Bagayam,Vellore | 
| 2011 | Neuro High Dependency Unit was renovated with 4 trauma ICU beds, a 12 bedded HDU and a 6 bedded trauma ward in 19th January 2011 | 
| 2011 | Clinical Neurophysiology Laboratory renovated on 13th June 2011 | 
| 2011 | Neurosurgery seats increased from 3 to 4 | 
| 2011 | 13th Annual Conference of Skull Base Surgery Society of India held in Bagayam, Vellore | 
| 2011 | 60th Year of the Department Celebrated | 
| 2012 | B.Sc. in Neuroelectrophysiology Started | 
| 2014 | IAN Clinical Neurophysiology Subsection Workshop On Electromyoneurography and Autonomic Disorders held in Bagayam | 
| 2016 | DM Neurology seats increased from 2 to 4 | 
| 2019 | D.M. Paediatric Neurology started with 2 seats | 
| 2019 | IAN First Master class in Paediatric Neurology held in CMC Bagayam | 
| 2019 | Platinum Jubilee of the Department Celebrated | 
| 2021 | M.Ch. Neurosurgery increased from 4 to 6 | 
| 2022 | Department of Neurological Sciences shifted from Vellore to Ranipet Campus | 
| 2023 | ISPN Course Midterm INDSPN CME held in September at CMC Ranipet Campus | 
| 2023 | First Annual Neuro Flash CME held in October at CMC Ranipet Campus | 
| 2024 | Diamond Jubilee of the Department and Alumni Reunion Celebrated at CMC Ranipet Campus |